T-cadherin suppresses the cell proliferation of mouse melanoma B16F10 and tumor angiogenesis in the model of the chorioallantoic membrane

Authors: Yurlova, E.; Rubina, K.; Sysoeva, V.; Sharonov, G.; Semina, E.; Parfenova, E.; Tkachuk, V.

Source: Russian Journal of Developmental Biology, Volume 41, Number 4, July 2010 , pp. 217-226(10)

Publisher: MAIK Nauka/Interperiodica

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Abstract:

The influence of T-cadherin on the pigmentation and proliferation of mouse melanoma B16F10 cells in vitro and on the growth and neovascularization of tumor cell masses formed by the B16F10 cells in a model of the chorioallantoic membrane of a chicken embryo is studied. It is found that the proliferative activity of the cells decreases in the cell culture of mouse melanoma upon the overexpression of T-cadherin in comparison with the cells in the control. It is shown in experiments in vitro that the B16F10 cells with the overexpression of T-cadherin are rarely settling are to the chorioallantoic membrane than the control cells. In addition, it is found that the control cells of mouse melanoma form tumors with area more 0.1 mm2 more often than the cells with the overexpression of T-cadherin and the amount of the vessels growing to tumor cell masses formed by the cells with the overexpression of T-cadherin is significantly lower than the same index for the cells in the control. Thus, the overexpression of T-cadherin in the B16F10 cells suppresses the proliferation of these cells in vitro and the growth of the tumor masses formed by melanoma cells on the chorioallantoic membrane and their neovascularization in vivo.

Keywords: T-cadherin; angiogenesis in the chorioallantoic membrane; tumor angiogenesis

Document Type: Research Article

DOI: http://dx.doi.org/10.1134/S1062360410040028

Affiliations: Email: rkseniya@mail.ru

Publication date: July 1, 2010

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