A Pipeline Architecture for Processing of DNA Microarrays Images: Genomic Signal Processing (Guest Editors: Yu-Ping Wang and Yu Hen Hu)

Authors: Shadrokh Samavi; Shahram Shirani; Nader Karimi; M. Jamal Deen

Source: The Journal of VLSI Signal Processing, Volume 38, Number 3, November 2004 , pp. 287-297(11)

Publisher: Springer

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Abstract:

In this paper we present a pipeline architecture specifically designed for processing of DNA microarray images. Many of the pixilated image generation methods produce one row of the image at a time. This property is fully exploited by a pipeline which takes in one row of the produced image at each clock pulse and performs the necessary image processing steps on it. This will remove the present need for sluggish software routines that are considered a major bottleneck in the microarray technology. The size of the proposed structure is a function of the width of the image and not its length. The proposed architecture is proved to be highly modular, scalable and suited for a Standard Cell VLSI implementation.

Keywords: microarray; DNA; pipeline processing; image processing; morphological operations

Document Type: Research article

DOI: http://dx.doi.org/10.1023/B:VLSI.0000042493.11467.64

Affiliations: 1: Department of Electrical and Computer Engineering, McMaster University, Hamilton, Ontario, Canada, L8S 4K1

Publication date: 2004-11-01