The effects of piroxicam to the muscosal barrier of the bladder after overdistension – an experimental study in rabbits
Author: Barlas M.1
Source: International Urology and Nephrology, Volume 34, Number 3, 2002 , pp. 321-324(4)
Publisher: Springer
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Abstract:
The effects of piroxicam on the duration and severity of damage to the mucosal barrier of the urinary bladder after overdistension was investigated. Overdistension of the bladder was induced for 3 h in 16 New Zealand male rabbits by giving Ringer's lactate infusion (40 ml/kg/h) and furosemide (1 mg/kg) to the peritoneal cavity. Insertion of 8 Fr Foley catheter was used for obstruction of the bladder neck. In both control (C) and piroxicam (P) groups, 20 mL of 2% solution of Trypan blue in 0.9% NaCl solution was instilled into the bladder for 1 hr at 0, 24, 48 h and 7 days after overdistension. In group P daily intramuscular injection of 5 mg/kg piroxicam, and isotonic saline in group C was administrated for 7 days. Full-thickness samples were taken from the bladder at 0, 24, 48 h and 7 days after overdistension. The bladder wall was deep blue throughout in both groups at 0, 24, and 48 h. The severity and duration of inflammatory reaction was lower and nearly normalized on the 7th post procedure day in piroxicam group. Conclusion: Inflammatory reaction can be prevented by administration of anti-inflammatory drugs such as piroxicam but the prevention of increased permeability is unclear after overdistension of the bladder.
Keywords: Bladder; Inflammation; Overdistension; Permeability; Proxicam
Language: English
Document Type: Research article
Affiliations: 1: Department of Pediatric Surgery, University of Ankara, School of Medicine, Ankara, Turkey (E-mail: meralbarlas@yahoo.com)
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