Genetic Susceptibility to Tuberculosis: From Monogenic to Polygenic Inheritance

Authors: Alcaïs A.¹; Remus N.²; Abel L.²; Casanova J-L.²

Source: Sepsis, Volume 4, Number 3, December 2001 , pp. 237-246(10)

Publisher: Springer

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Abstract:

Summary. Tuberculosis is re-emerging as a leading public health problem worldwide, largely due to the lack of a fully protective vaccine, the acquired immunodeficiency associated with HIV-co-infection and the increasing number of drug-resistant mycobacteria. There is substantial epidemiological evidence that the host genetic make-up affects the development of clinical tuberculosis in humans. Here we review population-based and patient-based molecular studies that have implicated various genes in polygenic and monogenic susceptibility to mycobacterial disease. We further discuss the possibility of a continuous spectrum between these two poles of tuberculosis genetics.

Keywords: HLA; interferon gamma; interleukin-1; interleukin-12; mannose-binding protein; NRAMPI; vitamin D-receptor

Language: English

Document Type: Regular paper

Affiliations: 1: Laboratory of Human Genetics of Infectious Diseases, Universit;ea Ren;ea Descartes - INSERM U550, Paris, France, EU alcais@necker.fr 2: Laboratory of Human Genetics of Infectious Diseases, Universit;ea Ren;ea Descartes - INSERM U550, Paris, France, EU

Publication date: 2001-12-01