Synthesis of substituted pyrido[1,2-a]pyrimidines from 2-arylmethylidene-3-fluoroalkyl-3-oxopropionates
Authors: Pryadeina, M.; Burgart, Ya.; Kodess, M.; Saloutin, V.
Source: Russian Chemical Bulletin, Volume 54, Number 12, December 2005 , pp. 2841-2845(5)
Abstract:Cyclocondensation of 2-arylmethylidene-3-fluoroalkyl-oxopropionates with 2-amino-pyridine occurs at both the polyfluoroacylvinyl and alkoxycarbonylvinyl fragments to give alkyl 4-aryl-2-polyfluoroalkyl-4H-pyrido[1,2-a]pyrimidine-3-carboxylates and 4-aryl-2-hydroxy-3-polyfluoroacyl-4H-pyrido[1,2-a]pyrimidines, respectively. When treated with copper(II) acetate, the pyrido[1,2-a]pyrimidines yield metal complexes.
Document Type: Research Article
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Publication date: December 1, 2005