Synthesis of substituted pyrido[1,2-a]pyrimidines from 2-arylmethylidene-3-fluoroalkyl-3-oxopropionates

Authors: Pryadeina, M.; Burgart, Ya.; Kodess, M.; Saloutin, V.

Source: Russian Chemical Bulletin, Volume 54, Number 12, December 2005 , pp. 2841-2845(5)

Publisher: Springer

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Abstract:

Cyclocondensation of 2-arylmethylidene-3-fluoroalkyl-oxopropionates with 2-amino-pyridine occurs at both the polyfluoroacylvinyl and alkoxycarbonylvinyl fragments to give alkyl 4-aryl-2-polyfluoroalkyl-4H-pyrido[1,2-a]pyrimidine-3-carboxylates and 4-aryl-2-hydroxy-3-polyfluoroacyl-4H-pyrido[1,2-a]pyrimidines, respectively. When treated with copper(II) acetate, the pyrido[1,2-a]pyrimidines yield metal complexes.

Keywords: 2-aminopyridine; 2-arylmethylidene-3-fluoroalkyl-3-oxopropionate; complex formation; cyclocondensation; pyrido[1,2-a]pyrimidine; regioisomerism

Document Type: Research Article

DOI: http://dx.doi.org/10.1007/s11172-006-0198-y

Affiliations: Email: saloutin@ios.uran.ru

Publication date: December 1, 2005

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