Authors: Meeske, Kathleen; Smith, Ashley; Alfano, Catherine; McGregor, Bonnie; McTiernan, Anne; Baumgartner, Kathy; Malone, Kathleen; Reeve, Bryce; Ballard-Barbash, Rachel; Bernstein, Leslie

Source: Quality of Life Research, Volume 16, Number 6, August 2007 , pp. 947-960(14)

Publisher: Springer

Abstract:

Purpose The purpose of this study was to estimate prevalence of fatigue, identify correlates of fatigue and evaluate the relationship between fatigue and health-related quality of life (HRQOL) in a large cohort of disease-free breast cancer survivors.

Methods Participants are enrolled in the HEAL Study, a multi-center prospective study of women diagnosed with in-situ to Stage IIIA breast cancer. HEAL participants (n = 1183) completed a baseline and a 24-month follow-up interview. Women in this report (n = 800) also completed a quality of life questionnaire that included the Piper Fatigue Scale and the RAND SF-36 two to five years after diagnosis. Multivariate regression methods were used to identify significant factors associated with fatigue. SF-36 scores for fatigued survivors were compared to non-fatigued survivor scores and population norms.

Results Forty-one percent of the breast cancer survivors were fatigued. Significant correlates of fatigue included pain, cognitive problems, physical inactivity, weight gain/personal appearance and antidepressant use. Fatigue was associated with poorer HRQOL, most notably in areas of role and social functioning.

Conclusion This study provides further support for the conclusion that a significant proportion of breast cancer survivors experience fatigue that compromises HRQOL two to five years post-diagnosis.

Keywords: Breast cancer survivors; Fatigue; Quality of life; Piper Fatigue Scale

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11136-007-9215-3

Affiliations: 1: Email: lbern@usc.edu

Publication date: 2007-08-01

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