Comparative effects of scopoletin and cyanide on rat brain, 1: Histopathology

Authors: Ezeanyika L.U.S.1; Obidoa O.2; Shoyinka V.O.3

Source: Plant Foods for Human Nutrition, Volume 53, Number 4, 1999 , pp. 351-358(8)

Publisher: Springer

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

Four week old male Wistar rats were used to study the effects of scopoletin and cyanide on the histopathology of rat brain. The rats were divided into a control and three experimental groups (2–4) and fed rations containing 0.07 mgrg scopoletin/100 g, 0.07mgrg scopoletin + 1.8 mg cyanide/100 g and 1.8 mg cyanide/100 g, respectively. These levels of scopoletin and cyanide corresponded to levels found in a processed cassava diet. The first group was fed the same ration as the others but without scopoletin and cyanide. The rats were fed these rations for twelve months. Rats from each group were sacrificed at the third, sixth, ninth and twelfth months; the relative brain weight of the rats (% of body weight) and histology of their brains were studied. The lipid peroxide levels of the rat brains were also studied at the twelfth month. The results showed that the relative brain weights of the rats fed scopoletin +cyanide were significantly (p<0.05) less than that of the control from the third month. There were no significant changes in the lipid peroxide levels of the rat brains in the various groups. Histological examination of the brains of the rats sugested that scopoletin is involved in the pathogenesis of the neuropathy seen in cassava consuming populations.

Keywords: Cassava toxicity; Cyanide; Neuropathy; Scopoletin

Language: English

Document Type: Regular paper

Affiliations: 1: Department of Biochemistry, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria 2: Department of Biochemistry, University of Nigeria, Nsukka, Nigeria 3: Department of Veterinary Microbiology and Pathology, University of Nigeria, Nsukka, Nigeria

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$47.00 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A