Novel Microneedle Patches for Active Insulin Delivery are Efficient in Maintaining Glycaemic Control: An Initial Comparison with Subcutaneous Administration

Authors: Nordquist, Lina; Roxhed, Niclas; Griss, Patrick; Stemme, Göran

Source: Pharmaceutical Research, Volume 24, Number 7, July 2007 , pp. 1381-1388(8)

Publisher: Springer

Abstract:

Good glycaemic control is essential to minimize the risk for diabetes-induced complications. Also, compliance is likely to be higher if the procedure is simple and painless. This study was designed to validate painless intradermal delivery via a patch-like microneedle array.

Diabetes was induced by an intravenous injection of streptozotocin (50 mg/kg bw) in adult male Sprague Dawley rats. Plasma insulin and blood glucose were measured before, during and after subcutaneous or intradermal (microneedles) infusion of insulin (0.2 IU/h) under Inactin-anaesthesia.

Before insulin administration, all animals displayed a pronounced hyperglycaemia (19 ± 1 mM; 359 mg/dl). Administration of insulin resulted in a reduced plasma glucose independently of administration route (subcutaneous 7.5 ± 4.2, n = 9, and intradermal 11 ± 1.8, n = 9 after 240 min), but with less errors of the mean in the intradermal group. In the intradermal group, plasma insulin was increased in all latter measurements (72 ± 22, 81 ± 34, and 87 ± 20 μIU/ml), as compared to the first measurement (26 ± 13). In the subcutaneous group, plasma insulin was elevated during the last measurement (to 154 ± 3.5 μIU/ml from 21 ± 18).

This study presents a novel possibility of insulin delivery that is controllable and requires minimal training. This treatment strategy could improve compliance, and thus be beneficial for patients' glycaemic control.

Keywords: diabetes; insulin lispro; intradermal; microneedles; rats; transdermal

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11095-007-9256-x

Affiliations: 1: Email: Lina.Nordquist@medcellbiol.uu.se

Publication date: 2007-07-01

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