IngentaConnect Novel Film Modifiers to Alter the Physical Properties of Composit...

Abstract:

Polyvinylpyrrolidone (PVP), molecular-composite PVP, and Plasdone S-630 copolyvidonum are potential polymeric film modifiers for achieving improved drug release. The aim of this study was to investigate how these polymeric additives would affect the physicomechanical properties of composite ethylcellulose films.

The miscibility of these polymeric additives with ethylcellulose was determined from the differential scanning calorimetry (DSC) thermograms of various polymer blends formed from organic solvents. It was found that ethylcellulose (EC) was miscible with the polymeric additives up to a concentration of 50%. Ten percent to 30% w/w polymeric additives were then added to aqueous ethylcellulose dispersion to form composite films. The morphology, film transparency, dynamic mechanical analysis (DMA) thermograms, and mechanical properties of the composite ethylcellulose films were studied. In addition, puncture strength and % elongation of the dry and wet films were also compared from indentation test.

Significant reduction and change in film transparency and morphology was obtained for EC films blended with PVP of higher molecular weight (MW). The composite EC films also showed higher T_g, greater elastic modulus, tensile and puncture strength depending on the concentration and type of additives present.

The interaction between ethylcellulose and the polymeric additives is dependent on the MW and concentration of additives. The composite films offer new opportunities for the use of ethylcellulose as modified release coatings for dosage forms.

Keywords: differential scanning calorimetry; dynamic mechanical analysis; ethylcellulose; mechanical test; polyvinylpyrrolidone

Document Type: Research article

DOI: 10.1007/s11095-004-1886-7

Affiliations: 1: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore, 2: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore, Email: phapaulh@nus.edu.sg

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$47.00 plus tax Refund Policy

Novel Film Modifiers to Alter the Physical Properties of Composite Ethylcellulose Films