IngentaConnect Hydrogel-Based lontotherapeutic Delivery Devices for Transdermal ...

Authors: Banga A.K.¹; Chien Y.W.²

Source: Pharmaceutical Research, Volume 10, Number 5, May 1993 , pp. 697-702(6)

Publisher: Springer

Abstract:

Hydrogels were synthesized as the drug reservoir matrix for peptide-based pharmaceuticals, and the iontophoretic release and transdermal delivery of three model peptides, insulin, calcitonin, and vasopressin, from these hydrogel-based iontotherapeutic devices were investigated. The swelling behavior of polyacrylamide-type hydrogel as a function of its monomer and cross-linker concentration was studied, and a hydrogel with minimal swelling was synthesized. The release of peptides from the hydrogel matrix was found to follow a Q vs t^½ relationship under passive diffusion conditions, which shifted to a Q vs t relationship under iontophoresis-facilitated transport. The release flux (dQ/dt) of peptides was observed to decline when the electric current was turned off and was resumed when the current was turned on, thus allowing for modulation of drug release by varying the application parameters of iontophoresis-facilitated transport. The permeability coefficients for these peptides across the hairless rat skin were evaluated using the hydrogel formulations prepared from polyacrylamide, p-HEMA, and carbopol. A rank order of vasopressin > calcitonin > insulin was obtained in accordance with the order of molecular size.

Keywords: transdermal; iontophoresis; insulin; calcitonin; vasopressin; hydrogel; polyacrylamide; p-HEMA

Language: English

Document Type: Regular paper

Affiliations: 1: Controlled Drug-Delivery Research Center, College of Pharmacy, Rutgers–The State University of New Jersey, P.O. Box 789, Piscataway, New Jersey 08855-0789. Current address: Department of Pharmacal Sciences, School of Pharmacy, Auburn University, Auburn, Alabama 36849-5503. 2: Controlled Drug-Delivery Research Center, College of Pharmacy, Rutgers–The State University of New Jersey, P.O. Box 789, Piscataway, New Jersey 08855-0789. To whom correspondence should be addressed.

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Hydrogel-Based lontotherapeutic Delivery Devices for Transdermal Delivery of Peptide/Protein Drugs