IngentaConnect A Quantitative Method of Evaluating the Diuretic Response to Furo...

Authors: Hori R.¹; Okumura K.²; Inui K-i.²; Shibata T.²; Kikkoji T.³; Kamiya A.²

Source: Pharmaceutical Research, Volume 5, Number 11, November 1988 , pp. 694-698(5)

Publisher: Springer

Abstract:

Furosemide effects are usually evaluated by measuring the urinary excretion rate of Na^+ (UV_Na) in humans. In the present study, however, UV_Na showed a nonlinear relationship with urine flow rate after intravenous injection of furosemide in rats. In contrast, when the urinary excretion rate of (Na^+ + K^+) (UV_Na+K) was plotted against the urine flow rate, a linear regression line was observed, with small interindividual variations in normal rats and in rats with uranyl nitrate-induced acute renal failure (ARF). Piretanide, a loop diuretic, also showed a similar relationship, while other types of diuretics revealed different slope values for the relationship. Although the urinary excretion rate of Cl^− (UV_C1) vs UV_Na+K is expected to show a linear relationship in normal rats, the correlation coefficient of the linear regression line was smaller than that of the urine flow rate vs UV_Na+K. Further, the slope of UV_C1 vs UV_Na+K was slightly different in ARF rats. Therefore, UV_Na+K provides a better quantitative measure of diuretic response to loop diuretics than UV_Na or UV_C1.

Keywords: furosemide; diuresis; sodium excretion; potassium excretion; chloride excretion; urinary excretion rate; urinary electrolytes in rats

Language: English

Document Type: Regular paper

Affiliations: 1: Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan. To whom correspondence should be addressed. 2: Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan. 3: Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan. Present address: Pharmaceutical Development Laboratories, Meiji Seika Kaisha, Ltd., Saiwai-ku, Kawasaki, Japan.

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A Quantitative Method of Evaluating the Diuretic Response to Furosemide in Rats