Thermal Decomposition of Thonzonium Bromide
Authors: Chafetz, L.1; Greenough, R.C.2; Frank, J.3
Source: Pharmaceutical Research, Volume 3, Number 5, 1 October 1986 , pp. 298-301(4)
Publisher: Springer
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Abstract:
Thonzonium bromide, a quaternary ammonium compound used as a surface active agent in a phenylephrine nasal solution, gave a gas chromatographic peak which was proportional in height and area to its concentration. Quaternary ammonium salts are nonvolatile and polar, thus the peak was attributed to a thermal decomposition product. It was identified as hexadecyldimethylamine by spectroscopic analysis and comparison with an authentic sample. A second product was identified by mass spectroscopy as 2[(2-hexadecylmethylaminoethyl)(4-methoxybenzylamino)] pyrimidine, the desmethyl bromide product. These decomposition products were detected in stability samples of formulations.Keywords: thonzonium bromide, thermal decomposition; quaternary ammonium derivatives, gas chromatograph; surface active agents, nasal solutions; stability of nasal formulations
Document Type: Research article
Affiliations: 1: Product Development Laboratories, Warner-Lambert Research Institute, Morris Plains, New Jersey 07950. Chafetz Associates, P.O. Box 990, Murray Hill, New Jersey 07974. 2: Product Development Laboratories, Warner-Lambert Research Institute, Morris Plains, New Jersey 07950. 3: Product Development Laboratories, Warner-Lambert Research Institute, Morris Plains, New Jersey 07950. Deceased, 1978.
- Free Content
- New Content
- Subscribed Content
- Free Trial Content
Click here for Page Help