Variations of in Vitro Nitroglycerine Permeation Through Human Epidermis

Authors: Langguth P.¹; Spahn H.²; Mutschler E.²

Source: Pharmaceutical Research, Volume 03, Number 1, February 1986 , pp. 61-63(3)

Publisher: Springer

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Abstract:

The fluxes of nitroglycerine (NG) through human abdominal epidermis from different individuals were measured in vitro at 32°C. The mean NG flux for the entire group was 16.9 µg/cm² × hr, with a standard deviation of 47.7%. There are no significant differences in the means and the variances of NG fluxes between males and females. In groups of different ages (36–58 and >60 years) the mean values are in the same range, whereas the variance is significantly higher in the elderly.

Keywords: nitroglycerine; permeation through skin; variability with age; human epidermis

Language: English

Document Type: Research article

Affiliations: 1: Institute of Pharmacology, Department of Biochemistry, Pharmacy and Food Chemistry, University of Frankfurt, D-6000 Frankfurt, Federal Republic of Germany. To whom correspondence should be addressed at Pharmakologisches Institut für Naturwissenschaftler, Theodor-Stern-Kai, Geb. 75 A, 6000 Frankfurt/Main, FRG. 2: Institute of Pharmacology, Department of Biochemistry, Pharmacy and Food Chemistry, University of Frankfurt, D-6000 Frankfurt, Federal Republic of Germany.

Publication date: 1986-02-01