Thermal Stability of Mefruside–Polyvinylpyrrolidone Solid Dispersions

Authors: Junginger H.E.¹; Wedler M.^{2, 3}

Source: Pharmaceutical Research, Volume 03, Number 1, February 1986 , pp. 41-44(4)

Publisher: Springer

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Abstract:

The stability of mefruside–polyvinylpyrrolidone (PVP) 30 solid dispersions at ratios of mefruside/PVP 30 of 9/1, 7/3, and 5/5 (g/g) after mechanical (tableting) and allothermic stressing (50, 60, and 70°C up to 240 hr) was investigated. Only the 5/5 (g/g) solid dispersion showed no recrystallization of mefruside, whereas a slight increase in crystallinity in the 7/3 (g/g) solid dispersion and a strong increase in the 9/1 (g/g) product were detected. The mechanisms of drug recrystallization in such “high-energy products” are discussed.

Keywords: mefruside; thermal stability; solid dispersions; polyvinylpyrrolidone

Language: English

Document Type: Research article

Affiliations: 1: Center for Bio-Pharmaceutical Sciences, Division of Pharmaceutical Technology, Leiden University, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden, The Netherlands. To whom correspondence should be addressed. 2: Institut für Pharmazeutische Technologic TU Braunschweig, M 3:

Publication date: 1986-02-01