Reversible Gastric Restriction Implant: Safety and Efficacy in a Canine Model
Source: Obesity Surgery, Volume 21, Number 9, September 2011 , pp. 1444-1450(7)
Abstract:Gastric restrictive procedures are considered effective weight loss treatment for severe obesity. The aim of the study was to evaluate the efficacy and safety of a reversible implant that renders a partial restriction of stomach in a canine model.
The device was comprised of two longitudinal parallel non-compressive plates with two C-rings to create a small gastric pouch that opposed gastric distension. Three groups of non-obese mongrel dogs were included: group I (n = 6) underwent surgical implant for 6 weeks, group II (n = 6) underwent surgical implant for 6 weeks, followed by surgical removal of the implant and additional monitoring for 5 weeks, and group III (n = 5) served as sham-operated controls for groups I and II. Food intake and body weight were monitored, and the stomachs were examined histologically postmortem.
The average food intake was significantly decreased by 38.2% in group I as compared to group III throughout the 6 weeks of surgical implant (P < 0.05). The implanted dogs showed a progressive weight loss as compared to sham, which reached 21% by the end of 6 weeks. In group II, after 5 weeks of implant removal, the body weights recovered to approximately 96% of baseline. Histological evidence of the implant site at the gastric walls revealed no significant structural changes, tissue ischemia, hemorrhage, or necrosis.
Our results validate the feasibility of a reversible gastric restriction implant in a non-obese canine model, with the potential for achieving significant weight loss within 6 weeks and with no injury to the gastric wall.
Document Type: Research Article
Affiliations: 1: Department of Biomedical Engineering, Indiana University–Purdue University Indianapolis, Indianapolis, IN, 46202, USA 2: Department of Surgery, IUPUI, Indianapolis, IN, USA 3: Department of Pathology, IUPUI, Indianapolis, IN, USA 4: Department of Surgery, Austral University, Buenos Aires, Argentina 5: Department of Biomedical Engineering, Indiana University–Purdue University Indianapolis, Indianapolis, IN, 46202, USA, Email: firstname.lastname@example.org
Publication date: 2011-09-01