GM1 Ganglioside Potentiates Trimethyltin-Induced Expression of Interleukin-1Beta and the Nerve Growth Factor in Reactive Astrocytes in the Rat Hippocampus: An Immunocytochemical Study

Authors: Oderfeld-Nowak B.; Zaremba M.

Source: Neurochemical Research, Volume 23, Number 3, March 1998 , pp. 443-453(11)

Publisher: Springer

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Abstract:

This study demonstrates potentiation by GM1 ganglioside treatment of trimethyltin (TMT) induced reactivity of astrocytes, and the expression of astroglial interleukin-lbeta (IL-1beta) and nerve growth factor (NGF) immunoreactivities in the rat hippocampus. GM1 treatment also results in an increase of the number of IL-1beta and NGF immunoreactive astrocytes. Both the intensity of gliosis and stimulation of IL-1beta and NGF expression in astrocytes mostly occurs in the regions of heaviest neurodegeneration in the hippocampus (CA4/CA3c and CA1). It is tempting to assume that enhancement of astroglial NGF expression by GM1 ganglioside may play a role in the protective action of GM1 against neurotoxic insult.

Keywords: GM1 ganglioside; glial fibrillary acidic protein; astrocytes; nerve growth factor; interleukin-lbeta; hippocampus; trimethyltin neurotoxicity

Language: English

Document Type: Research article

Affiliations: 1: Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Science, 3 Pasteur St. 02093 Warszawa, Poland

Publication date: 1998-03-01