Suppression of synthesis of serotonin: Effect on antinociception induced by microwave irradiation and analgesic remedies

Author: Nesin, E.¹

Source: Neurophysiology, Volume 38, Numbers 5-6, September 2006 , pp. 427-428(2)

Publisher: Springer

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Abstract:

We studied isolated and combined antinociceptive effects of analgesics (Analginum and Tramadol), as well as of microwave irradiation of an acupuncture point, in mice under conditions of suppression of synthesis of serotonin by an inhibitor of this synthesis, DL-p-chlorophenylalanine (p-CPA). Preliminary introduction of p-CPA weakened the antinociceptive effect of microwave irradiation and also moderated the combined effects of analgesics and microwave irradiation.

Keywords: analgesia; formalin test; analgesics; microwave irradiation; DL-p-chlorophenylalanine

Document Type: Research article

DOI: 10.1007/s11062-006-0082-2

Affiliations: 1: Email: gonchar@biph.kiev.ua

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