Non-opioid-induced tolerance in rats

Authors: Tsiklauri, N.; Tsagareli, M.

Source: Neurophysiology, Volume 38, Number 4, July 2006 , pp. 314-317(4)

Publisher: Springer

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Abstract:

It is shown that systemic injections of analgin and ketorolac in doses equivalent to those used in clinics induce antinociception in awake rats (tail-flick test) and, when carried out repetitively, induce tolerance to these agents and cross-tolerance to morphine (blocked by naloxone).

Keywords: cross-tolerance; non-opioid analgesics; tail-flick reflex

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11062-006-0065-3

Affiliations: 1: Email: tsagareli@biphysiol.ge

Publication date: 2006-07-01