Clinical analysis of paraneoplastic encephalitis associated with ovarian teratoma

Authors: Tonomura, Yasuyo; Kataoka, Hiroshi1; Hara, Yasuo; Takamure, Miwa; Naba, Itirou; Kitauti, Takanori; Saito, Kozue; Ueno, Satoshi

Source: Journal of Neuro-Oncology, Volume 84, Number 3, September 2007 , pp. 287-292(6)

Publisher: Springer

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

Recently, paraneoplastic encephalitis associated with ovarian teratoma has been described and related to an autoantibody. Methods: We describe four patients with ovarian teratoma-associated encephalitis (OTE) and compared their clinical pictures with those of 17 previously reported patients with OTE. Results: Clinically, OTE was characterized by the development of acute prominent psychiatric symptoms (20 of 21 patients), seizures (15 of 21 patients), and central hypoventilation (13 of 21 patients). Our patients had hypersalivation (three patients) and cardiac conduction problems (all patients); hypothermia was present in one patient. The mean time from the onset of OTE to tumor diagnosis was 19.6 ± 22.1 weeks. Ventilatory support was required for 54.9 ± 25.4 days on average. The white blood cell count in cerebrospinal fluid was 55.1 ± 61.2/mm3. Twelve patients showed abnormalities on cranial MRI, involving areas such as the temporal regions (seven patients) or brainstem (four patients). In addition to tumor resection, 17 patients received some type of immunotherapy: 17 patients received corticosteroids, 10 received intravenous immunoglobulins, two received cyclophosphamide, seven received plasma exchange. Eighteen patients with OTE had neurological improvement, including 11 with full recovery. Conclusions: OTE presents with cardiac conduction problems and hypersalivation in addition to psychiatric symptoms, seizures, and central hypoventilation.

Keywords: Encephalitis; Limbic encephalitis; Teratoma; Ovarian tumor; Paraneoplastic encephalitis

Document Type: Research article

DOI: 10.1007/s11060-007-9372-9

Affiliations: 1: Email: hk55@naramed-u.ac.jp

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$47.00 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A