A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT

Authors: Nakagawa, Toshio; Maeda, Masayuki; Kato, Mikiyoshi; Terada, Naohiro; Shimizu, Shigetoshi; Morooka, Yoshito; Nakano, Hiroshi; Takeda, Kan

Source: Journal of Neuro-Oncology, Volume 84, Number 2, September 2007 , pp. 185-188(4)

Publisher: Springer

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Abstract:

Lhermitte-Duclos Disease (LDD) is a rare cerebellar lesion that has long been controversial as to whether the entity is a hamartoma, a malformation, or a neoplasm. Recent advances in metabolic imaging and molecular biology have unveiled biological features of LDD and a close relationship between LDD and Cowden disease. Adult onset LDD is now considered identical to Cowden disease in a US guideline. We present a case of LDD, in which high fluorodeoxy glucose (FDG) uptake was shown on PET/CT. We performed dual time point scans, in which a delayed scan exhibited more intense FDG uptake by the hamartomatous lesion than an early scan. We must remain aware of the possibility of LDD when intense accumulation is observed in a cerebellar lesion on FDG-PET/CT imaging.

Keywords: Lhermitte-Duclos disease; Cowden disease; F-18 fluorodeoxy glucose (FDG); Positron emission tomography/computed tomography (; Dual time point; Delayed scan

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11060-007-9355-x

Affiliations: 1: Email: mmaeda@clin.medic.mie-u.ac.jp

Publication date: 2007-09-01