Durable response of a radiation-induced, high-grade cerebellar glioma to temozolomide

Authors: Monje, Michelle; Ramakrishna, Naren; Young, Geoffrey; Drappatz, Jan; Doherty, Lisa; Wen, Patrick; Kesari, Santosh

Source: Journal of Neuro-Oncology, Volume 84, Number 2, September 2007 , pp. 179-183(5)

Publisher: Springer

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Abstract:

Radiation-induced high-grade gliomas are a rare but serious late complication of radiotherapy. We report a patient with radiation-induced cerebellar high-grade glioma who had a durable response to temozolomide.

Case report of a 77-year-old woman with a radiation-induced, high-grade cerebellar glioma that responded durably to temozolomide.

Our patient developed a cerebellar high-grade glioma 9 years after treatment for a stage IV (T4N0M0) supraglottic laryngeal squamous cell carcinoma with cisplatinum and fluorouracil chemotherapy, and subsequently focal head and neck radiotherapy. Patient was treated with radiation and concurrent temozolomide (only partially due to toxicity) and was stable for 1 year without further adjuvant treatment. Subsequently the tumor recurred and the patient had a dramatic and durable response to standard 5 day dosing of adjuvant temozolomide.

High-grade gliomas are a late complication of radiation to the central nervous system and may respond to chemotherapy.

Keywords: Chemotherapy; PET; Radiation-induced glioma; Temozolomide

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11060-007-9354-y

Affiliations: 1: Email: skesari@partners.org

Publication date: 2007-09-01