The anti-cancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells

Authors: Ping, Yi-fang; Yao, Xiao-hong; Chen, Jian-hong; Liu, Hong; Chen, Dai-lun; Zhou, Xiang-dong; Wang, Ji; Bian, Xiu-wu

Source: Journal of Neuro-Oncology, Volume 84, Number 1, August 2007 , pp. 21-29(9)

Publisher: Springer

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Abstract:

The chemokine receptor CXCR4 plays an important role in tumor growth, angiogenesis and metastasis. Our previous studies showed that Nordy, a synthetic chiral compound of nordihydroguaiaretic acid, inhibited the growth and angiogenesis of various malignant tumors. In this study we examined the capacity of Nordy to regulate CXCR4-mediated production of angiogenic factors by human glioblastoma cells. We found that Nordy potently inhibited CXCR4 ligand SDF-1-induced production of IL-8 and vascular endothelial cell growth factor, two important angiogenic factors implicated in the progression of malignant tumors. Further study revealed that the effect of Nordy was attributable to its down-regulation of the expression of functional CXCR4 in glioblastoma cells. These results suggest that the anti-cancer activity of Nordy is due, at least in part, to its suppression of the chemokine receptor CXCR4 thus reducing the production of angiogenic factors by tumor cells.

Keywords: Chemokine receptor CXCR4; Stromal cell-derived factor-1; Nordy; Interleukin-8; Vascular endothelial growth factor; Glioma

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11060-007-9349-8

Affiliations: 1: Email: bianxiuwu@263.net

Publication date: 2007-08-01