Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report

Authors: Kageji, Teruyoshi; Nagahiro, Shinji; Matsuzaki, Kazuhito; Kanematsu, Yasuhiko; Nakatani, Minoru; Okamoto, Yasuhiko; Watanabe, Tsutomu

Source: Journal of Neuro-Oncology, Volume 83, Number 2, June 2007 , pp. 199-204(6)

Publisher: Springer

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Abstract:

We report a 17-year-old male with disseminated intracranial choriocarcinoma at the basal ganglia whose consciousness level was very low at diagnosis. He received neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy prior to radical excision of the tumor. Postoperatively he was treated with three courses of high-dose chemotherapy (carboplatin (CBDCA), methotrexate (MTX), and etoposide (VP-16)) and peripheral blood stem-cell transplantation. This combination of therapies resulted in tumor regression on MRI and remarkable improvement in his neurological condition. Ours is the first report of the effectiveness of NAT followed by radical surgery in a patient with disseminated primary intracranial choriocarcinoma.

Keywords: Choriocarcinoma; Intracranial tumor; Germ cell tumor; Chemotherapy; Radiation

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s11060-006-9311-1

Affiliations: 1: Email: kageji@clin.med.tokushima-u.ac.jp

Publication date: 2007-06-01