Quantifying Gene Networks with Regulatory Strengths

Authors: de la Fuente A.; Mendes P.

Source: Molecular Biology Reports, Volume 29, Numbers 1-2, 2002 , pp. 73-77(5)

Publisher: Springer

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Abstract:

A gene network is the collection of regulatory relationships between all genes in a genome. Gene networks are high-level descriptions of cellular biochemistry and show the phenomenological interactions between gene activities. These interactions are mediated by proteins and metabolites. In the gene network approach, only the transcriptome is considered and all biochemistry underlying gene-gene interactions is only implicitly present. In a previous work, we presented a method for inferring gene networks from experimental data, quantifying gene-gene interactions with regulatory strengths. Here, we show how to express these regulatory strengths in terms of properties of the whole biochemical network.

Keywords: Gene Networks; Metabolic Control Analysis; Metabolome; Proteome; Transcriptome

Language: English

Document Type: Research article

Affiliations: 1: Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, 1880 Pratt Drive, Blacksburg, VA 24061, U.S.A.

Publication date: 2002-01-01