Thermal behavior of anti-hypertensives drugs in solution and human plasma using DSC-cooling

Authors: da Silva Simőes, Mônica; Gomes, A.; do Nascimento, T.; Macêdo, R.

Source: Journal of Thermal Analysis and Calorimetry, Volume 72, Number 2, May 2003 , pp. 539-544(6)

Publisher: Springer

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Abstract:

The present study proposes the use of DSC-cooling as a fast tool to evaluate the drug behavior in biofluids submitted to freeze-thaw studies. Captopril, captopril+ascorbic acid and propranolol in plasma were submitted to 3 cycles of freeze-thaw using DSC-cooling up to 243 K. Captopril-plasma has suffered calorimetric alteration and revealed a considerable interaction front to freezing and heating processes. The presence of additive can stabilize the analyte in plasma. Propranolol-plasma presented reducing in phase transition enthalpy comparable to the plasma denatured by perchloric acid in the last cycles of freezing. DSC-cooling data demonstrated great potentiality for the freeze-thaw studies of drugs in biofluids.

Keywords: anti-hypertensives drugs; freeze-thaw cycles; biofluids interactions; DSC-cooling

Document Type: Research article

DOI: http://dx.doi.org/10.1023/A:1024521531539

Affiliations: 1: Email: ruimacedo@ltf.ufpb.br

Publication date: 2003-05-01