Authors: de Souza, Nadábia; Medeiros, Ana; Santos, Ana; Macêdo, R.1
Source: Journal of Thermal Analysis and Calorimetry, Volume 72, Number 2, May 2003 , pp. 535-538(4)
Publisher: Springer
Abstract:
TG and DSC data were used to determine the thermal parameters of metronidazole drug and tablets. Three tablets A, B and C were analysed. The TG curves of metronidazole drug and tablets A and B displayed five and C four thermal decomposition processes, respectively. Analysis of the DSC data pointed to chemical interactions between metronidazole drug and the excipients of tablets, suggested by alterations in the melting point of metronidazole. The rate constants obtained from the isothermal TG data presents following sequence of the thermal stability: tablet A>tablet C>metronidazole drug>tablet B.Keywords: dissolution rate constants; DSC-photovisual; pharmaceutical equivalence; cimetidine; metronidazole; thermal analysis
Document Type: Research article
DOI: 10.1023/A:1024569414701
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