Thermal stability of metronidazole drug and tablets

Authors: de Souza, Nadábia; Medeiros, Ana; Santos, Ana; Macêdo, R.¹

Source: Journal of Thermal Analysis and Calorimetry, Volume 72, Number 2, May 2003 , pp. 535-538(4)

Publisher: Springer

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Abstract:

TG and DSC data were used to determine the thermal parameters of metronidazole drug and tablets. Three tablets A, B and C were analysed. The TG curves of metronidazole drug and tablets A and B displayed five and C four thermal decomposition processes, respectively. Analysis of the DSC data pointed to chemical interactions between metronidazole drug and the excipients of tablets, suggested by alterations in the melting point of metronidazole. The rate constants obtained from the isothermal TG data presents following sequence of the thermal stability: tablet A>tablet C>metronidazole drug>tablet B.

Keywords: dissolution rate constants; DSC-photovisual; pharmaceutical equivalence; cimetidine; metronidazole; thermal analysis

Document Type: Research article

DOI: 10.1023/A:1024569414701

Affiliations: 1: Email: ruimacedo@ltf.ufpb.br

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