A Simple Absorption Model for Dose-escalating Studies

Author: Källén, Anders1

Source: Journal of Pharmacokinetics and Pharmacodynamics, Volume 34, Number 2, April 2007 , pp. 251-261(11)

Publisher: Springer

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

A simple model for absorption that generalizes zero and first order absorption processes is discussed. We show how traditional methods can be used to investigate how reasonable this model is, and discuss the effects of the absorption model on classical PK parameters. The methods are illustrated with two real-life data sets from dose-escalating studies.

Keywords: nonlinear absorption; pharmacokinetics

Document Type: Research article

DOI: 10.1007/s10928-006-9047-8

Affiliations: 1: Email: anders.kallen@astrazeneca.com

* This feature is in beta and some links may initially be displayed as numbers instead of article titles. Clicking on any of the links will take you to the recommended articles, regardless of the display of the link.

The full text article is available for purchase

$42.00 plus tax

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A