A Simple Absorption Model for Dose-escalating Studies

Author: Källén, Anders

Source: Journal of Pharmacokinetics and Pharmacodynamics, Volume 34, Number 2, April 2007 , pp. 251-261(11)

Publisher: Springer

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Abstract:

A simple model for absorption that generalizes zero and first order absorption processes is discussed. We show how traditional methods can be used to investigate how reasonable this model is, and discuss the effects of the absorption model on classical PK parameters. The methods are illustrated with two real-life data sets from dose-escalating studies.

Keywords: nonlinear absorption; pharmacokinetics

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10928-006-9047-8

Affiliations: 1: Email: anders.kallen@astrazeneca.com

Publication date: 2007-04-01