Crystal structure of the cytotoxic marine alkaloid 2-bromoleptoclinidinone

Authors: Lindsay, B.S.; Oliver, A.G.; Rickard, C.E.F.; Copp, B.R.

Source: Journal of Chemical Crystallography, Volume 28, Number 8, August 1998 , pp. 645-648(4)

Publisher: Springer

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Abstract:



2-Bromoleptoclinidinone methanol solvate, C18H8BrN3O·CH4O, crystallizes in the orthorhombic space group Pbca with a = 15.7013(2), b = 7.3308(1), and c = 26.9326(1) Å. The molecule is essentially planar, with the largest deviations occurring at bromine (-0.21 Å), carbonyl oxygen O(l) (+0.19 Å) and in ring-A (C(9) -0.15 Å, C(10) -0.15 Å). Methanol occupies the 1,10-phenanthroline-like metal binding site of the title compound.

Keywords: 2-Bromoleptoclinidinone; crystal structure; cytotoxic; marine alkaloid

Document Type: Research Article

Affiliations: Department of Chemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand

Publication date: August 1, 1998

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