Different Scenarios for Inter-Protein Electron Tunneling: The Effect of Water-Mediated Pathways

Authors: Miyashita O.; Axelrod H.L.; Onuchic J.N.

Source: Journal of Biological Physics, Volume 28, Number 3, 2002 , pp. 383-394(12)

Publisher: Springer

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Abstract:

Recent theoretical developments now allow for reliable calculation of tunneling matrix elements in unimolecular biological electron transfer reactions that have been tested experimentally. Most biological ET processes, however, are bimolecular, or involve large-scale protein domain motions. In this paper, initial advances in this direction by studying the inter-protein electron transfer between cytochrome c₂ and the photosynthetic reaction center. Utilizing an approach that integrates molecular dynamics and the Pathways method, we have observed that the ensemble dominant tunneling pathways in this reaction go though the tyrosine 162 or are water mediated.

Keywords: biological tunneling; pathways; photosynthetic reaction center; water mediated pathways

Language: English

Document Type: Research article

Affiliations: 1: University of California, San Diego, 9500 Gilman Dr, La Jolla, California, U.S.A.

Publication date: 2002-01-01