Brief Report: Clonazepam Behavioral Side Effects with an Individual with Mental Retardation
Authors: Kalachnik J.E.1; Hanzel T.E.2; Sevenich R.3; Harder S.R.4
Source: Journal of Autism and Developmental Disorders, Volume 33, Number 3, June 2003 , pp. 349-354(6)
Publisher: Springer
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Abstract:
Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums. These side effects may be inadvertently confused with other behavioral or psychiatric conditions, especially if exacerbation of existing challenging behavior occurs. This report describes an individual with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day (0.02 mg/kg/day) to treat aggression, self-injurious behavior, property destruction, and screaming, which was measured with a 15-minute partial interval recording measurement method. When clonazepam was reduced and discontinued, these behaviors significantly decreased from 3.1% of intervals (95% confidence band = 1.6% to 4.6%) to 0.1% of intervals (95% confidence band = 0% to 0.1%). Indicators suggesting review by appropriate medical personnel for possible clonazepam behavioral side effects are provided.
Keywords: Benzodiazepines; clonazepam; mental retardation; side effects; behavioral side effects; aggression
Language: English
Document Type: Short communication
Affiliations: 1: University of South Carolina, School of Medicine, Department of Pediatrics, Center for Disability Resources, Columbia, South Carolina. jkalach@dhs.state.ia.us 2: Hanzel Consulting, New Prague, Minnesota 3: Department of Psychiatry, HealthEast Care System, St. Joseph's Hospital, St. Paul, Minnesota 4: St. Croix River Education District, Rush City, Minnesota
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