Brief Report: Effects of Clozapine on Self-Injurious Behavior of Two Risperidone Nonresponders with Mental Retardation

Authors: Hammock R.1; Levine W.R.1; Schroeder S.R.2

Source: Journal of Autism and Developmental Disorders, Volume 31, Number 1, February 2001 , pp. 109-113(5)

Publisher: Springer

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Abstract:

A typical antipsychotic medications for self-injurious behavior (SIB), aggression, and destruction among people with mental retardation and development disabilities are becoming increasingly accepted. Most studies are on risperidone and fewer have been conducted on clozapine. The present single-blind study reports marked reductions in SIB and aggression of two persons with profound mental retardation who were nonresponsive to all other behavioral and psychopharmacological interventions, including risperidone. The most effective dose was 200 mg/day. Side effects were mild and the drug was tolerated well.

Keywords: Self-injurious behavior; risperidone; clozapine

Language: English

Document Type: Regular paper

Affiliations: 1: Creative Community Living, Inc., Winfield, Kansas. 2: Address all correspondence to Stephen R. Schroeder, Director, Bureau of Child Research, Dole, University of Kansas, Lawrence, Kansas 66045.

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