Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection

Authors: Parrella, Paola; Seripa, Davide; Matera, Maria; Rinaldi, Monica; Signori, Emanuela; Gravina, Carolina; Gallo, Antonietta; Prencipe, Maria; Grandone, Elvira; Mariani, Luciano; Cordiali, Paola; Carlo, Aldo; Stentella, Patrizia; Pachì, Antonio; Fazio, Vito

Source: European Journal of Epidemiology, Volume 22, Number 3, March 2007 , pp. 159-162(4)

Publisher: Springer

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Abstract:

Genetic variants in the immunomodulatory gene mannose-binding lectin 2 (MBL2), were associated with risk, severity, and frequency of viral infections. In a case-control setting, we investigated the association of MBL2 functional polymorphisms with Human Papillomas Virus (HPV) infection. No differences between cases (HPV⁺) and controls (HPV^-) were found in the distribution of each single genotypes or allele. Haplotype analysis did not show any difference between HPV+ and HPV^- groups.

Keywords: Genetic variants; Gynecological cancer/cervical; Host-virus interaction; HPV; MBL2

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10654-007-9111-8

Affiliations: 1: Email: pparrella@operapadrepio.it

Publication date: 2007-03-01