Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil
Authors: Kato I.1; Vogelman J.H.2; Dilman V.1; Karkoszka J.1; Frenkel K.1; Durr N.P.2; Orentreich N.2; Toniolo P.1
Source: European Journal of Epidemiology, Volume 14, Number 6, September 1998 , pp. 621-626(6)
Publisher: Springer
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Abstract:
Recent in vitro studies have shown that chromium (III) compounds such as chromium picolinate, a popular dietary supplement among people trying to lose weight, produce chromosome damage. We monitored levels of DNA damage in a chromium picolinate supplement trial by measuring antibodies titers to an oxidized DNA base, 5-hydroxymethyl-2'-deoxyuridine (HMdU), by enzyme-linked immunosorbent assays. Ten obese volunteer women completed a 8-week course of 400 
g chromium picolinate per day. In either absolute titers or percent of the baseline value, there were no changes in antibody titers at 4 or 8 weeks. The titers were very stable within individuals and those of one individual rarely crossed over others, which was reflected in an intraclass correlation coefficient of 0.99 (95% confidence interval: 0.96–1.00). There were no effects on glucose and lipid metabolism in this period. The results of this trial suggest that chromium (III) picolinate in a dose typically used for nutrient supplementation dose not increase oxidative DNA damage, as measured by anti-HMdU antibody levels.
Keywords: Autoantibodies; Chromium picolinate; Dietary supplement; DNA damage; HMdU
Language: English
Document Type: Regular paper
Affiliations: 1: Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, NY 2: Orentreich Foundation for the Advancement of Science, Inc., Biomedical Research Station, Cold-Spring-on-Hudson, NY, USA
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