Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil

Authors: Kato I.¹; Vogelman J.H.²; Dilman V.¹; Karkoszka J.¹; Frenkel K.¹; Durr N.P.²; Orentreich N.²; Toniolo P.¹

Source: European Journal of Epidemiology, Volume 14, Number 6, September 1998 , pp. 621-626(6)

Publisher: Springer

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Abstract:

Recent in vitro studies have shown that chromium (III) compounds such as chromium picolinate, a popular dietary supplement among people trying to lose weight, produce chromosome damage. We monitored levels of DNA damage in a chromium picolinate supplement trial by measuring antibodies titers to an oxidized DNA base, 5-hydroxymethyl-2'-deoxyuridine (HMdU), by enzyme-linked immunosorbent assays. Ten obese volunteer women completed a 8-week course of 400 mgr g chromium picolinate per day. In either absolute titers or percent of the baseline value, there were no changes in antibody titers at 4 or 8 weeks. The titers were very stable within individuals and those of one individual rarely crossed over others, which was reflected in an intraclass correlation coefficient of 0.99 (95% confidence interval: 0.96–1.00). There were no effects on glucose and lipid metabolism in this period. The results of this trial suggest that chromium (III) picolinate in a dose typically used for nutrient supplementation dose not increase oxidative DNA damage, as measured by anti-HMdU antibody levels.

Keywords: Autoantibodies; Chromium picolinate; Dietary supplement; DNA damage; HMdU

Language: English

Document Type: Regular paper

Affiliations: 1: Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, NY 2: Orentreich Foundation for the Advancement of Science, Inc., Biomedical Research Station, Cold-Spring-on-Hudson, NY, USA

Publication date: 1998-09-01