Electrophysiological analysis of visual function in mutant mice

Authors: Peachey N.S.¹; Ball S.L.²

Source: Documenta Ophthalmologica, Volume 107, Number 1, July 2003 , pp. 13-35(23)

Publisher: Springer

Buy & download fulltext article:

Price: $47.00 plus tax (Refund Policy)

Abstract:

The mouse has become a key animal model for ocular research. This situation reflects the fact that genes implicated in human retinal disorders or in mammalian retinal function may be readily manipulated in the mouse. Visual electrophysiology provides a means to examine retinal function in mutant mice, and stimulation and recording protocols have been developed that allow the activity of many classes of retinal neurons to be examined and which take into account unique features of the mouse retina. Here, we review the mouse visual electrophysiology literature, covering techniques used to record the mouse electroretinogram and visual evoked potential, and how these have been applied to characterize the functional implications of gene mutation or manipulation in the mouse retina.

Keywords: animal model; electroretinogram (ERG); gene mutation; mouse; retina; visual evoked potential (VEP)

Language: English

Document Type: Research article

Affiliations: 1: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA;Research Service, Cleveland VA Medical Center, Cleveland, OH 44106, USA; Departments of Neurosciences and Psychology 2: Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA;Research Service, Cleveland VA Medical Center, Cleveland, OH 44106, USA; Departments of Neurosciences , Case Western Reserve University, Cleveland, OH 44106, USA

Publication date: 2003-07-01