Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration

Authors: Lau D.; Flannery J.

Source: Documenta Ophthalmologica, Volume 106, Number 1, January 2003 , pp. 89-98(10)

Publisher: Springer

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Abstract:

These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.

Keywords: light damage; neurotrophic factor; retinal gene therapy

Language: English

Document Type: Research article

Affiliations: 1: School of Optometry and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA

Publication date: 2003-01-01