Intravenous Pantoprazole as Initial Treatment in Patients With Gastroesophageal Reflux Disease and a History of Erosive Esophagitis: A Randomized Clinical Trial

Authors: Pratha, Vijaya; Hogan, Daniel; Lynn, Richard; Field, Brian; Metz, David

Source: Digestive Diseases and Sciences, Volume 51, Number 9, September 2006 , pp. 1595-1601(7)

Publisher: Springer

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Abstract:

We sought to evaluate safety and efficacy of IV pantoprazole when used as initial therapy in patients with gastroesophageal reflux disease (GERD) and a history of erosive esophagitis (EE) in a double-blind, placebo-controlled, randomized, parallel-group study. Patients were randomized to 7 days of once-daily IV or oral pantoprazole (40 mg) or placebo. Efficacy variables included maximal acid output, basal acid output, and changes from baseline in frequency/severity of GERD symptoms, and frequency of antacid usage. Seventy-eight patients were randomized (n=26/27/25 [IV/oral/placebo]). Mean maximal acid output was 8.4, 6.3, and 20.9 mEq/h for IV or oral pantoprazole, and placebo, respectively. For pantoprazole versus placebo, maximal and basal acid output were significantly lower (P<.001) and there was a numerical trend toward improved GERD and antacid usage. Both treatments were well tolerated. In conclusion, IV/oral pantoprazole were similarly effective in suppressing basal and pentagastrin-stimulated gastric acid secretion in GERD patients with a history of EE.

Keywords: Intravenous pantoprazole; GERD; Basal acid output; Maximal acid output

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10620-006-9108-2

Affiliations: 1: Email: dhogan@calincresearch.com

Publication date: 2006-09-01