Monitoring Cytochrome P-450 Activity During Rabeprazole Treatment in Patients with Gastresophageal Reflux Disease

Authors: Giannini, Edoardo; Savarino, Vincenzo; Testa, Roberto

Source: Digestive Diseases and Sciences, Volume 51, Number 9, September 2006 , pp. 1602-1606(5)

Publisher: Springer

Abstract:

Proton pump inhibitors (PPIs) are the cornerstone in the treatment of gastresophageal reflux disease (GORD). PPIs are metabolized by the hepatic cytochrome P-450 enzymes (CYP-450). Rabeprazole is a PPI whose metabolism shows fewer interactions compared to other PPIs.

In this study we evaluated the influence of rabeprazole administration on hepatic CYP-450 activity as measured by the ¹³C-aminopyrine breath test (¹³C-ABT) in a group of patients with GORD.

¹³C-ABT was performed on five GORD patients both before and after 1 week of rabeprazole administration (20 mg, b.i.d.). Pretreatment ¹³C-ABT results were compared to posttreatment results. Pre- and posttreatment ¹³C-ABT results for patients were compared to those obtained in five controls who did the test twice, with a 1-week interval in between. Before treatment, the ¹³C-ABT results for the GORD patients did not significantly differ from those of healthy subjects. After treatment, we observed no significant modification of the ¹³C-ABT in GORD patients compared to pretreatment values (¹³C-ABT %dose/hr, 10.56±1.31 versus 11.17±0.88; ¹³C-ABT %cumulative dose, 8.08±1.11 versus 8.34±0.56). Posttreatment ¹³C-ABT results were not significantly different from those obtained in controls at weekly repetition of the test. In patients with GORD, 1-week, full-dose rabeprazole does not display any significant interactions with CYP-450 activity.

Keywords: Rabeprazole; Liver function; 13C-aminopyrine breath test

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10620-005-9035-7

Affiliations: 1: Email: egiannini@unige.it

Publication date: 2006-09-01

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