Direct Autoradiographic Evidence that Rebamipide Interacts with Neutrophils in Dextran Sulfate Sodium Induced Colitis in Rats
Authors: Nakamura, Masahiko1; Takahashi, Tetsufumi2; Matsumoto, Tsukasa3; Atsuda, Koichiro4; Hibi, Norifumi5; Matsui, Hidenori3; Yamada, Haruki2; Tsuchimoto, Kanji4
Source: Digestive Diseases and Sciences, Volume 50, Supplement 1, October 2005 , pp. S113-S118(1)
Publisher: Springer
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Abstract:
To determine the effects of rebamipide during the early stages of colitits development, colitis was induced in rats by oral administration of dextran sulfate sodium for 3 or 7 days. The target sites of 3H-rebamipide were examined by intra-aortic infusion of the radiolabeled compound followed by autoradiography. 3H-rebamipide was localized in goblet cells in the colon of the control rat, whereas it accumulated in the cytoplasm of mesenchymal cells in dextran sulfate sodium treated rats, localized predominatly to polymorphonuclear leucocytes.Keywords: dextran sulfate sodium; rebamipide; autoradiography; colitis; neutrophil
Document Type: Research article
DOI: 10.1007/s10620-005-2815-2
Affiliations: 1: Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan, Email: nakamuram@pharm.kitasato-u.ac.jp 2: Graduate School of Pharmaceutical Science, Kitasato University, Japan, 3: Kitasato Institute for Life Sciences & Graduate School of Infection Control Science, Kitasato University, Japan, 4: Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan, 5: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan,
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