IngentaConnect Prevention by Rebamipide of Acute Reflux Esophagitis in Rats

Authors: Katada, Kazuhiro¹; Yoshida, Norimasa²; Isozaki, Yutaka¹; Tomatsuri, Naoya¹; Ichikawa, Hiroshi¹; Naito, Yuji³; Okanoue, Takeshi³; Yoshikawa, Toshikazu¹

Source: Digestive Diseases and Sciences, Volume 50, Supplement 1, October 2005 , pp. S97-S103(1)

Publisher: Springer

Abstract:

Proinflammatory factors, including neutrophil-derived oxygen free radicals and inflammatory cytokines, have recently been implicated in the pathogenesis of reflux esophagitis. Rebamipide has been widely used as an anti-ulcer agent. The aim of the present study was to assess the protective effect of rebamipide against acute reflux esophagitis in rats. Esophagitis was induced in rats by ligation at the limiting ridge and the lower portion of the duodenum. Vehicle or rebamipide were given as a single dose intraduodenally. Lesion index (LI), thiobarbituric acid-reactive substances (TBA-RS), myeloperoxidase (MPO) activity, mRNA and protein of tumor necrosis factor (TNF)- alpha

and cytokine-induced neutrophil chemoattractant (CINC)-1 in the esophageal mucosa were markedly increased; pretreatment with rebamipide, however, significantly reduced both macroscopic and microscopic injuries and increases in inflammatory mediators. The results of this study indicate that rebamipide protects against the occurrence of esophagitis and has highly promising potential as a new therapeutic agent for reflux esophagitis.

Keywords: reflux esophagitis; rebamipide; neutrophils; lipid peroxidation; TNF- alpha ; CINC-1

Document Type: Research article

DOI: 10.1007/s10620-005-2813-4

Affiliations: 1: Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan, 2: Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan, Email: nyoshida@koto.kpu-m.ac.jp 3: Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan,

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