Interdigestive Gallbladder Emptying, Antroduodenal Motility, and Motilin Release Patterns Are Altered in Cholesterol Gallstone Patients

Authors: Stolk M.F.J.¹; Erpecum K.J.V.¹; Peeters T.L.²; Samsom M.¹; Smout A.J.P.M.¹; Akkermans L.M.A.¹; Vanberge-Henegouwen G.P.¹

Source: Digestive Diseases and Sciences, Volume 46, Number 6, June 2001 , pp. 1328-1334(7)

Publisher: Springer

Abstract:

The role of interdigestive gallbladder emptying in gallstone formation is unknown. In fasting healthy subjects, gallbladder emptying is associated with antral phase III of the migrating motor complex (MMC) and high plasma motilin. Therefore, gallbladder volumes and motilin levels were measured during 13 MMC cycles in 10 cholesterol gallstone patients and compared with 20 MMC cycles in 10 healthy subjects. MMC cycle length was longer in gallstone patients than in healthy subjects (158.2 ± 17.0 vs 105.5 ± 10.4 min, respectively; P < 0.05), due to longer phase I (39.8 ± 5.7 vs 17.2 ± 3.7 min, respectively; P < 0.05). In contrast to healthy subjects, gallstone patients had no significant fluctuations of gallbladder volume during the MMC cycle, and motilin concentrations were not different in MMC cycles with phase III originating in antrum or duodenum. During MMC cycles with phase III originating in the duodenum, motilin levels were twice as high in gallstone patients as in healthy subjects (P < 0.002). In conclusion, cholesterol gallstone patients have an abnormal MMC and motilin release pattern. Their interdigestive gallbladder emptying is reduced and dissociated from the MMC. These disturbances may contribute to gallstone formation.

Keywords: cholesterol gallstone; gallstone formation; gallbladder motility; migrating motor complex; motilin

Language: English

Document Type: Regular paper

Affiliations: 1: Gastrointestinal Research Unit, Departments of Gastroenterology and Surgery, University Hospital, Utrecht, The Netherlands. 2: Gut Hormone Laboratory, Gasthuisberg, University Leuven, Leuven, Belgium.

Publication date: 2001-06-01

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• In this Subject: Gastroenterology
• By this author: Stolk M.F.J. ;  Erpecum K.J.V. ;  Peeters T.L. ;  Samsom M. ;  Smout A.J.P.M. ;  Akkermans L.M.A. ;  Vanberge-Henegouwen G.P.

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