Chemical Modification of Plant Alkaloids. 2. Reaction of Cotarnine with Barbituric Acid Derivatives and Structure of 5-Dihydrocotarnylbarbituric Acids
Source: Chemistry of Natural Compounds, Volume 37, Number 6, November 2001 , pp. 543-550(8)
Abstract:The reaction of barbituric acid and its N-substituted derivatives and 2-thio analogs with cotarnine forms 5-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-2H-1,3-methylenedioxy-[4,5-g]isoquinoli nyl-1)barbituric acids, a new class of zwitter-ions, the structure of which was studied by ^1H and ^13C NMR spectroscopy and mass spectrometry. The prepared compounds exist in solution as stable intermolecular associates and have a complicated H-bonded structure.
Document Type: Regular Paper
Affiliations: 1: I. I. Mechnikov St. Petersburg State Medical Academy, 195067, St. Petersburg, Piskarevskii pr., 47 2: ZAO "InterBioScreen," 142432, Chernogolovka, Moscow District, Institutskii pr., 8
Publication date: 2001-11-01