Home >> Cellular and Molecular Neurobiology, Volume 31, Number 4

Adenosine 5′-Triphosphate-Sensitive Potassium Channel Activator Induces the Up-Regulation of Caveolin-1 Expression in a Rat Brain Tumor Model

Authors: Gu, Yan-ting1; Xue, Yi-xue2; Zhang, Hua3; Li, Yan4; Liang, Xin-yuan4

Source: Cellular and Molecular Neurobiology, Volume 31, Number 4, May 2011 , pp. 629-634(6)

Publisher: Springer

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Abstract:

This study was performed to determine whether minoxidil sulfate (MS), a selective Adenosine 5′-triphosphate-sensitive potassium channel (K ATP channel) activator, has an effect on the expression of caveolin-1 in the rat's brain tumor tissue. Using a rat brain glioma (C6) model, we found that the expression of caveolin-1 protein at tumor sites was greatly increased after intracarotid infusion of MS at a dose of 30 μg/kg/min for 15, 30, and 60 min via Western blot analysis. And the peak value of the caveolin-1 expression was observed in rats with glioma after 15 min of MS perfusion, which was significantly attenuated by reactive oxygen species (ROS) scavenger (N-2-mercaptopropionyl glycine, MPG). In addition, MPG also significantly inhibited the increase of blood-brain tumor barrier (BTB) permeability which was induced by MS. This led to the conclusion that the MS-induced BTB permeability increase may be related to the accelerated formation of caveolin-1 protein, and could be mediated by ROS.

Keywords: Adenosine 5′-triphosphate-sensitive potassium channel; Glioma; Reactive oxygen species; Caveolin-1

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10571-011-9658-5

Affiliations: 1: Department of Physiology, Life Science and Biology Pharmacopedia Institution, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning Province, People's Republic of China, Email: yantinggu008@yahoo.com.cn 2: Department of Neurobiology, College Basic of Medicine, China Medical University, Shenyang, 110001, Liaoning Province, People's Republic of China, Email: xueyixue888@yahoo.com.cn 3: Department of Neurobiology, College Basic of Medicine, China Medical University, Shenyang, 110001, Liaoning Province, People's Republic of China 4: Department of Physiology, Life Science and Biology Pharmacopedia Institution, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning Province, People's Republic of China

Publication date: 2011-05-01

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