Severe Sinus Bradycardia after Initiation of Bupropion Therapy: A Probable Drug-Drug Interaction with Metoprolol

Authors: David L. McCollum¹; Jerica L. Greene²; Darren K. McGuire³

Source: Cardiovascular Drugs and Therapy, Volume 18, Number 4, July 2004 , pp. 329-330(2)

Publisher: Springer

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Abstract:

Bupropion is an increasingly prescribed agent to aid in smoking cessation. However it has important drug-drug interactions related to the cytochrome P450 system. One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol.

Keywords: metoprolol; bupropion; cytochrome P450; bradycardia

Document Type: Research article

DOI: http://dx.doi.org/10.1023/B:CARD.0000041254.15807.98

Affiliations: 1: Department of Internal Medicine, The University of Texas-Southwestern Medical Center at Dallas; Dallas,Texas 2: Department of Clinical Pharmacy, Dallas VA Medical Center, Dallas, Texas 3: Department of Internal Medicine, The University of Texas-Southwestern Medical Center at Dallas; Dallas,Texas; The Donald W. Reynolds Cardiovascular Clinical Research Center at UT-Southwestern, Dallas, Texas., Email: darren.mcguire@utsouthwestern.

Publication date: 2004-07-01