A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage

Authors: Esteban, F.; Muñoz, M.; González-Moles, M.; Rosso, M.

Source: Cancer and Metastasis Reviews, Volume 25, Number 1, March 2006 , pp. 137-145(9)

Publisher: Springer

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Abstract:

In the present review we discuss a central role for substance P (SP) in carcinogenesis. We suggest that one mechanism to induce mitogenesis of tumor cells is the activation of neurokinin-1 receptor (NK1R) through SP, linking cancer promotion and progression to a neurokinin-mediated environment. After reviewing the role of both SP and its receptor NK1R in normal and neoplastic cells we propose the use of neurokinin-1 receptor antagonists as a novel and promising approach for treating patients with cancer.

Keywords: Substance P; Neurokinin 1 receptor; Carcinogenesis; Antitumor; Oncogenesis; Neurokinin-1 receptor antagonists; G-protein-coupled receptor

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s10555-006-8161-9

Publication date: 2006-03-01