IngentaConnect Neo-adjuvant chemotherapy for operable breast cancer induces apop...

Authors: Shao Z-m.¹; Li J.¹; Wu J.¹; Han Q-x.¹; Shen Z-z.¹; Fontana J.A.²; Barsky S.H.³

Source: Breast Cancer Research and Treatment, Volume 53, Number 3, February 1999 , pp. 263-269(7)

Publisher: Springer

Abstract:

The use of neo-adjuvant chemotherapy (often referred to as pre-operative or primary chemotherapy) represents a major change in the management of breast cancer as a systemic disease. Laboratory studies have shown that many anti-cancer agents with differing modes of action achieve cytotoxic effects by inducing apoptosis. In this study, we investigated the induction of apoptosis by neo-adjuvant chemotherapy in human breast cancer. The aim was to determine whether a correlation existed between post chemotherapy apoptotic index (AI) and clinical response and patients' survival. Our results indicate that apoptosis is induced by neo-adjuvant chemotherapy and that the response is variable. Our data show that post chemotherapy AI correlated with clinical response and increased patient survival, including both relapse (disease) free survival and overall survival. Post-neo-adjuvant chemotherapy AI levels in primary breast cancer may possibly predict an individual patient's overall response.

Keywords: apoptosis; breast cancer; neo-adjuvant chemotherapy

Language: English

Document Type: Regular paper

Affiliations: 1: Department of Surgery, Molecular Biology Lab, Cancer Hospital, Shanghai Medical University, Shanghai, 200032, China 2: University of Maryland Cancer Center, Baltimore, MD 21201, USA 3: Department of Pathology and UCLA/Revlon Breast Center, UCLA, Los Angeles, CA 90024, USA

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Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis