Sex steroid binding protein receptor (SBP-R) is related to a reduced proliferation rate in human breast cancer

Authors: Catalano M.G.1; Comba A.1; Fazzari A.2; Benedusi-Pagliano E.1; Sberveglieri M.3; Revelli A.3; Massobrio M.3; Frairia R.2; Fortunati N.1

Source: Breast Cancer Research and Treatment, Volume 42, Number 3, February 1997 , pp. 227-234(8)

Publisher: Springer

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

In the last years, an increasing amount of studies described a membrane receptor for the Sex Steroid Binding Protein (SBP) on several androgen-estrogen dependent tissues. One of the suggested biological roles of the interaction between SBP and its receptor seems to be a negative control of the E_{2}induced proliferation of human breast cancer cells through the cAMP pathway. In the present work, SBP membrane receptor was evaluated on human breast cancer specimens with a radio-binding assay. Each tissue sample was also evaluated for ER and PGR status. Cytosol Thymidine Kinase levels were measured in tissue samples in order to evaluate cell proliferation rate. SBP binding to membranes of ER +/PGR +samples was time and temperature dependent, specific and at high affinity. In addition, SBP recognized on breast cancer membranes two sites at different affinity, as previously described for other human tissues and cultured cells. Membrane SBP-R was detected in a significantly higher number of samples positive for both ER and PGR than in negative samples. SBP-R positive samples showed a significantly lower proliferation rate than SBP-R negative samples as demonstrated by TK activity. The present study contains evidences for the existence of a specific membrane receptor for SBP in breast cancer sample membranes and the presence of SBP-R seems to be strictly related to a lower proliferation rate of the sample.

Keywords: breast cancer; membrane receptor; SBP; SHBG; thymidine kinase

Language: English

Document Type: Regular paper

Affiliations: 1: II Divisione Universitaria di Medicina Generale 2: Dipartimento di Fisiopatologia Clinica 3: Istituto di Ginecologia e Ostetricia, Cattedra D, Torino University Medical School, Torino, Italy

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$47.00 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A