Opportunities for Nanotechnology-Based Innovation in Tissue Proteomics

Authors: David H. Geho¹; Nicholas Lahar²; Mauro Ferrari³; Emanuel F. Petricoin⁴; Lance A. Liotta¹

Source: Biomedical Microdevices, Volume 6, Number 3, September 2004 , pp. 231-239(9)

Publisher: Springer

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Abstract:

Within this review we discuss two methodologies used in tissue proteomics, namely mass-spectrometry (MS)-based protein pattern diagnostics and protein microarrays. Further, we describe current goals within the field of tissue proteomics and suggest points of departure for designing nanotechnology-based tools that will enhance the role of molecularly based diagnostics and therapeutics development in clinical medicine.

Keywords: tissue proteomics; nanotechnology; protein micro-arrays; mass spectrometry

Document Type: Research article

DOI: http://dx.doi.org/10.1023/B:BMMD.0000042053.51016.b4

Affiliations: 1: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA gehod@mail.nih.gov, Email: gehod@mail.nih.gov 2: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA 3: Department of Internal Medicine, Division of Haematology and Oncology, and Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA 4: FDA-NCI Clinical Proteomics Program, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA

Publication date: 2004-09-01