Opportunities for Nanotechnology-Based Innovation in Tissue Proteomics
Authors: David H. Geho1; Nicholas Lahar2; Mauro Ferrari3; Emanuel F. Petricoin4; Lance A. Liotta1
Source: Biomedical Microdevices, Volume 6, Number 3, September 2004 , pp. 231-239(9)
Publisher: Springer
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Abstract:
Within this review we discuss two methodologies used in tissue proteomics, namely mass-spectrometry (MS)-based protein pattern diagnostics and protein microarrays. Further, we describe current goals within the field of tissue proteomics and suggest points of departure for designing nanotechnology-based tools that will enhance the role of molecularly based diagnostics and therapeutics development in clinical medicine.Keywords: tissue proteomics; nanotechnology; protein micro-arrays; mass spectrometry
Document Type: Research article
DOI: 10.1023/B:BMMD.0000042053.51016.b4
Affiliations: 1: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA gehod@mail.nih.gov, Email: gehod@mail.nih.gov 2: FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA 3: Department of Internal Medicine, Division of Haematology and Oncology, and Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA 4: FDA-NCI Clinical Proteomics Program, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
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