Fluidic Microchannel Arrays for the Electrophoretic Separation and Detection of Bioanalytes using Electrochemiluminescence

Authors: Yan, K.Y.; Smith, R.L.; Collins, S.D.

Source: Biomedical Microdevices, Volume 2, Number 3, 1 June 2000 , pp. 221-229(9)

Publisher: Springer

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Abstract:

In this paper a low cost, multi-channel separation and detection system is reported for use in fast, high throughput screening of bioanalytes. Applications include genetic engineering and drug discovery, particularly combinatorial chemistry. A prototype detection system is presented which is comprised of an array of 50 microchannels fabricated on 25 mm×75 mm glass substrates with planar, thin film metal electrodes for electrophoresis and electrochemiluminescence excitation. Fluidic interconnects to the microchannels via standard tubing provide quick and facile interfacing to external macro components, controllers and/or other microsystems. The fabrication process is readily scalable to higher density arrays.

Keywords: wafer bonding; combinatorial chemistry screening; electrophoretic system; electrochemiluminescence

Document Type: Regular paper

Affiliations: 1: Department of Electrical & Computer Engineering, MicroInstruments and Systems Laboratory (MISL), University of California, Davis, Davis, California

Publication date: 2000-06-01