Membrane Fusion Induced by Phospholipase C and Sphingomyelinases

Authors: Goñi F.M.; Alonso A.

Source: Bioscience Reports, Volume 20, Number 6, December 2000 , pp. 443-463(21)

Publisher: Springer

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Abstract:

In the past decade lipid vesicle fusion induced by either bacterial PC-preferring phospholipase C, phosphatidylinositol-specific phospholipase C, sphingomyelinase, or a combination of phospholipase C and sphingomyelinase has been demonstrated. In the present paper, the experimental evidence is reviewed, and discussed in terms of the underlying molecular mechanisms of fusion, and of the possible physiological relevance of these findings.

Keywords: Phospholipase C; sphingomyelinase; membrane fusion; liposomes; model membranes; non-bilayer lipids; non-lamellar lipid phase

Language: English

Document Type: Regular paper

Affiliations: 1: Unidad de Biofisica (CSIC-UPV/EHU), and Departamento de Bioquímica, Universidad des País Vasco, Aptdo. 644, 48080 Bilbao, Spain

Publication date: 2000-12-01